Modular prestressed concrete pressure Tank

(11) EP 3 671 006 A1

(22) 21.12.2018

(43) 24.06.2020 Bulletin 2020/26

(57) The present disclosure relates to novel nucleotide precursors and nucleotide analogs that can be in­corporated into oligonucleotides, including dou­ble-stranded oligonucleotides such as siRNAs. Oligonu­cleotides containing these analogs have superior biolog­ical activity, for example, increased in vitro stabil ity and improved in vivo potency especially duration of action. The improved oligonucleotides are useful for silencing (e.g., reducing or eradicating) the expression of a target gene. In particular embodiments, this invention encom­passes specific nucleotide analogs to be included in dou­ble-stranded RNAs (dsRNAs), and especially in siRNAs, that can hybridize to messenger RNAs (mRNAs) of in­terest, so as to reduce or block the expression of target genes of interest.

(71) Soletanche Freyssinet, 92500 Rueil-Malmaison, FR

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